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S urF AC T S i n Biomaterials...

September-October 2010 Volume 15 Issue 5...

From the Editor...

Nanoscale Thermo-Mechanical Analysis of Biomaterial and Polymeric Surfaces...

By Steven Goodman, 10H Technology Inc. Khoren Sahagian, Anasys Instruments Corporation Andy Hung, Boston Scientific Roshan Shetty, Anasys Instruments Corporation The Anasys Instruments Corporation Vesta is a novel instrument that uniquely measures the surface thermo-mechanical materials properties of medical polymers, coatings, drugs, and devices via Local Thermal Analysis (LTA) and Transition Temperature Microscopy (TTM). LTA and TTM assess thermal materials properties similar to conventional bulk thermo-mechanical analysis (TMA), but unlike TMA or DSC (differential scanning calorimetry), measurements are obtained on any identified specific region of a device. Thus, LTA and TTM uniquely enable the spatial imaging of thermal material properties. Thermal property measurement provides information on MW, crystallinity, drug component mixing, and can provide insight into mechanisms of localized degradation, wear and/or failure of devices after testing or following clinical use. The Vesta Instrument incorporates a micro-machined inverted pyramidal thermal probe that is fabricated on an AFM-like (atomic force microscope) cantilever. Users locate regions of interest using the Vesta's integrated optical microscope, and the Vesta then automatically engages the 30 nm radius thermal probe into contact with the sample surface. The Vesta thermal probe then rapidly heats up to a user-determined maximum temperature as high as 450 C, while monitoring the probe vertical position. This generates a Local Thermal Analysis (LTA) measurement. With most Thermo-Mechanical Analysis Continued on Page 3 What's Inside...

Implantable Silk Metamaterials Could Advance Biomedicine, Biosensing Tufts University Pg. 4...

From the Editor Continued on Page 2...

Synthetic Polymer Mimics Antimicrobial Properties of Host-Defense Proteins Pg. 5 Titanium Foams Replace Injured Bones Pg. 6...

Heal and Run A New Stent M.O. Pg. 7 NanoInk Releases Two New Nanoscale Applications Pg. 8...

Zimmer Looks to Thwart Biofilm Formation on Implants Pg. 8 Medtronic Advances Research on Drug-Eluting Balloons Pg. 9...

DSM and DuPont Announce Joint Venture Pg. 11...

From the Editor...

By Steven L. Goodman, Ph.D., 10H Technology Corporation...

SurFACTS in Biomaterials is the official publication of the foundation and is dedicated to serving industrial...

Document Keywords

Goodman, S., Sahagian, K., Hung, A., and Shetty, R. Nanoscale TMA of biomaterial and polymeric surfaces SurFACTS in Biomaterials, Sep - Oct 2010 surfaces nl sept oct10

About ANASYS INSTRUMENTS CORP.

Anasys Instruments delivers products that measure nanoscale material properties. Their products offer chemical, mechanical, and thermal analysis at the sub - 100nm scale.

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