Quantcast
Industry Cortex

Document Brief

Drug Discovery Today Volume 14, Numbers 3/4 February 2009...

Reviews KEYNOTE REVIEW...

Micro- and nanofluidic systems for high-throughput biological screening...

Jongin Hong1,2, Joshua B. Edel1,2 and Andrew J. deMello1...

Department of Chemistry, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom 2 Institute of Biomedical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom...

High-throughput screening (HTS) is a method of scientific experimentation widely used in drug discovery and relevant to the fields of biology. The development of micro- and nanofluidic systems for use in the biological sciences has been driven by a range of fundamental attributes that accompany miniaturization and massively parallel experimentation. We review recent advances in both arraying strategies based on nano/ microfluidics and novel nano/microfluidic devices with high analytical throughput rates. Introduction...

Recent advances in genomics, proteomics, cellomics and metabolomics have provided an opportunity for the pharmaceutical industry to accelerate the pace of drug discovery using high-throughput techniques 1 11 . The sequencing of the human genome has generated several new molecular targets with unknown functions as well as those with known functions. Rapid progress in proteomic research has begun to enable an understanding of the physiological and metabolic pathways of cells, the cultivation of disease therapies and the discovery of new smallmolecule drug candidates. Cellomics and metabolomics provide more comprehensive pictures of cells under complex physiological parameters. The increase in experimental complexity demands the organization, interpretation and utilization of experimental data in a methodical and rational manner and thus high-throughput screening (HTS) technologies have emerged to meet this demand. Current microplate-based HTS methods typically involve robotics, liquid handling devices, sensitive detectors and software for data processing and control. The combination of these components in theory allows many thousands of biochemical, genetic, proteomic or pharmacological tests to be performed in a parallel. Furthermore, HTS methods facilitate the understanding of human biological pathways that require large sets of experimental data to study genes, proteins and metabolites. The primary route to saving time and minimizing usage of biological samples involves miniaturization of existin...

Document Keywords

Micro - and Nanofluidic Systems for High - Throughput Biological Screening fileadmin user upload pro cleaner micro and nanofluidic systems for high throughput biological screening

About Bioforce Nanosciences, Inc.

Contact

515-233-8333, 800-631-8127 (toll free)
Fax: 515-233-8337

sponsored links